Summary for peptidase A02.012: retropepsin (human T-cell leukemia virus)

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Nameretropepsin (human T-cell leukemia virus)
Other namessimian T-cell leukemia virus endopeptidase, human T-cell lymphotropic virus 1 protease, HTLV-1 protease
Domain architecture
MEROPS Classification
Classification Clan AA >> Subclan (none) >> Family A2 >> Subfamily X >> A02.012
Holotyperetropepsin (human T-cell leukemia virus) (human T-cell lymphotropic virus type 1), Uniprot accession P14074 (peptidase unit: 455-564), MERNUM MER0016601
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeAspartic
PeplistIncluded in the Peplist with identifier PL00033
NC-IUBMBNot yet included in IUBMB recommendations.
PhysiologyProcessing of viral polyprotein.
Pharmaceutical relevanceDrug target for human leukemia.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patterntp/k/Vi/LScissile bondPvf/Vil/q/p (based on 12 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 0 0 0 0 0 1
Pro 3 0 0 0 7 0 0 5
Ala 2 0 0 0 0 0 1 1
Val 0 1 7 0 3 8 0 0
Leu 0 0 1 10 0 2 0 2
Ile 0 0 4 0 0 2 2 0
Met 1 0 0 0 0 0 2 0
Phe 0 0 0 0 1 0 0 0
Tyr 0 0 0 1 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 0 2 0 0 0 0 0 1
Thr 4 1 0 0 0 0 1 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 0 0 0
Gln 0 2 0 0 0 0 5 0
Asp 0 0 0 0 0 0 1 0
Glu 0 1 0 0 0 0 0 0
Lys 1 5 0 0 0 0 0 0
Arg 1 0 0 0 0 0 0 0
His 0 0 0 0 0 0 0 2