Summary for peptidase A02.013: bovine leukemia virus retropepsin

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Namebovine leukemia virus retropepsin
Other namesretropepsin (bovine leukemia virus)
Domain architecture
MEROPS Classification
Classification Clan AA >> Subclan (none) >> Family A2 >> Subfamily A >> A02.013
Holotypebovine leukemia virus retropepsin, Uniprot accession P10270 (peptidase unit: 48-159), MERNUM MER0000981
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeAspartic
PeplistIncluded in the Peplist with identifier PL00034
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (3 cleavages)
PhysiologyProcessing of viral polyprotein.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternS/qa/N/YlScissile bondP/I/V/Q (based on 17 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 1 0 1 0 0 0 0
Pro 3 0 0 0 15 0 0 1
Ala 0 3 0 1 0 0 0 1
Val 0 1 1 0 1 0 13 0
Leu 1 1 0 4 1 1 0 0
Ile 0 0 2 0 0 15 3 0
Met 0 1 0 1 0 0 0 0
Phe 0 1 0 1 0 0 0 0
Tyr 0 0 0 9 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 13 0 0 0 0 1 0 1
Thr 0 0 0 0 0 0 0 0
Cys 0 0 1 0 0 0 0 0
Asn 0 0 13 0 0 0 0 0
Gln 0 7 0 0 0 0 0 13
Asp 0 0 0 0 0 0 1 0
Glu 0 1 0 0 0 0 0 0
Lys 0 1 0 0 0 0 0 0
Arg 0 0 0 0 0 0 0 0
His 0 0 0 0 0 0 0 0