Summary for peptidase A02.015: Rous sarcoma virus retropepsin

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

 

Names
MEROPS NameRous sarcoma virus retropepsin
Other namesavian myeloblastosis virus retropepsin, avian sarcoma virus endopeptidase, RSV protease, retropepsin (Rous sarcoma virus), avian leucosis virus endopeptidase, retropepsin (avian myeloblastosis virus)
Domain architecture
MEROPS Classification
Classification Clan AA >> Subclan (none) >> Family A2 >> Subfamily X >> A02.015
HolotypeRous sarcoma virus retropepsin (Rous avian sarcoma virus), Uniprot accession P03322 (peptidase unit: 583-700), MERNUM MER0000972
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeAspartic
PeplistIncluded in the Peplist with identifier PL00035
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (2 cleavages)
PhysiologyProcessing of viral polyprotein in fowl pathogen.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternS/q/N/YlScissile bondP/I/V/Q (based on 18 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 1 0 0 0 0 0 0
Pro 2 0 0 0 14 0 0 0
Ala 2 2 1 1 1 1 2 0
Val 0 1 3 0 0 3 14 0
Leu 0 2 0 3 1 1 0 2
Ile 0 0 1 0 0 13 0 0
Met 0 0 0 1 0 0 1 0
Phe 1 1 0 1 0 0 0 0
Tyr 0 0 0 10 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 13 0 0 1 0 0 0 0
Thr 0 2 0 0 2 0 0 1
Cys 0 0 0 0 0 0 0 0
Asn 0 0 13 0 0 0 0 1
Gln 0 8 0 0 0 0 0 13
Asp 0 0 0 0 0 0 0 0
Glu 0 0 0 0 0 0 0 1
Lys 0 1 0 0 0 0 0 0
Arg 0 0 0 0 0 0 1 0
His 0 0 0 0 0 0 0 0