Summary for peptidase A05.001: thermopsin

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates Inhibitors

 

Names
MEROPS Namethermopsin
Other namesSsMTP (Sulfolobus solfataricus)
Domain architecture
MEROPS Classification
Classification Clan (unassigned) >> Subclan (none) >> Family A5 >> Subfamily (none) >> A05.001
Holotypethermopsin (Sulfolobus acidocaldarius), Uniprot accession P17118 (peptidase unit: 32-330), MERNUM MER0001319
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeAspartic
PeplistIncluded in the Peplist with identifier PL00038
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.23 (Aspartic endopeptidases) >> Peptidase 3.4.23.42
EnzymologyBRENDA database
Proteolytic eventsCutDB database (6 cleavages)
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/flScissile bond-/-/-/- (based on 18 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 2 1 2 0 0 2 1 2
Pro 2 0 1 0 0 1 1 2
Ala 1 3 1 1 2 3 1 1
Val 1 2 1 2 3 2 1 1
Leu 2 2 3 5 2 3 4 2
Ile 0 0 0 0 0 0 0 0
Met 0 0 0 0 0 0 0 0
Phe 1 1 2 5 1 0 0 0
Tyr 1 1 1 2 3 2 1 1
Trp 0 0 0 0 0 0 0 0
Ser 2 2 0 0 0 0 1 0
Thr 0 1 0 0 1 1 1 0
Cys 0 0 0 0 0 0 0 0
Asn 1 0 1 0 0 1 1 0
Gln 0 1 0 1 0 0 1 0
Asp 0 0 0 0 0 0 0 0
Glu 2 1 3 1 1 1 1 1
Lys 0 0 0 1 0 0 1 1
Arg 1 1 0 0 0 0 0 1
His 1 1 2 0 1 0 0 2