Summary for peptidase A08.001: signal peptidase II

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Namesignal peptidase II
Other namesleader peptidase II, lspA g.p. (Escherichia coli), premurein leader peptidase, prolipoprotein-leader peptidase, prolipoprotein signal peptidase
Domain architecture
MEROPS Classification
Classification Clan AC >> Subclan (none) >> Family A8 >> Subfamily (none) >> A08.001
Holotypesignal peptidase II (Escherichia coli), Uniprot accession P00804 (peptidase unit: 1-164), MERNUM MER0001313
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeAspartic
PeplistIncluded in the Peplist with identifier PL00040
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.23 (Aspartic endopeptidases) >> Peptidase 3.4.23.36
EnzymologyBRENDA database
Proteolytic eventsCutDB database (1 cleavage)
PhysiologyProcessing of numerous bacterial secreted lipoproteins.
Pharmaceutical relevanceReported to be a major virulence determinant of Mycobacterium tuberculosis and perhaps a promising new drug target (Sander et al., 2004).
Pathways KEGGProtein export