Summary for peptidase A09.001: spumapepsin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

 

Names
MEROPS Namespumapepsin
Other nameshuman spumaretrovirus polyprotein peptidase, foamy virus polyprotein peptidase
Domain architecture
MEROPS Classification
Classification Clan AA >> Subclan (none) >> Family A9 >> Subfamily (none) >> A09.001
Holotypespumapepsin (human spumaretrovirus), Uniprot accession P14350 (peptidase unit: 14-180), MERNUM MER0001439
History Identifier created: MEROPS 3.02 (25 June 1998)
Activity
Catalytic typeAspartic
PeplistIncluded in the Peplist with identifier PL00041
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (7 cleavages)
PhysiologyViral polyprotein processing peptidase.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternr/-/Vie/nfScissile bond-/Vi/t/- (based on 11 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 2 0 0 0 0 1 3
Pro 1 0 0 0 1 0 0 1
Ala 0 3 0 1 2 0 0 1
Val 0 1 6 0 0 7 0 0
Leu 0 1 0 0 0 0 1 0
Ile 0 1 4 0 0 2 0 0
Met 0 0 0 0 0 0 0 0
Phe 0 0 0 2 0 0 0 0
Tyr 1 0 0 1 1 0 0 0
Trp 0 1 0 0 0 0 0 0
Ser 0 0 0 0 1 0 0 0
Thr 0 1 0 0 3 1 6 2
Cys 0 0 0 0 1 0 0 0
Asn 0 0 0 6 1 1 0 0
Gln 1 0 0 0 1 0 0 2
Asp 1 0 0 0 0 0 1 0
Glu 1 0 1 0 0 0 0 0
Lys 0 0 0 0 0 0 1 1
Arg 4 0 0 1 0 0 0 0
His 2 1 0 0 0 0 1 1