Summary for peptidase A22.004: signal peptide peptidase-like protein 2B

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Human EST Mouse EST Substrates Inhibitors


MEROPS Namesignal peptide peptidase-like protein 2B
Other namesimpas 4 peptidase, IMP4, intramembrane protease 4, PSH4, presenilin homologue-4, SPPL2b protein, SPPL2B g.p. (Homo sapiens)
Name and HistorySignal peptide peptidase-like 2B is a transmembrane, aspartic endopeptidase that performs regulated intramembrane proteolysis of type II transmembrane proteins (Mentrup et al., 2015). It is primarily expressed at the cell surface (Behnke et al., 2011). It is known to cleave tumour necrosis factor alpha at multiple sites, releasing an intracellular domain that moves to the nucleus and triggers interleukin-12 production (Friedmann et al., 2006, Fluhrer et al., 2006). Other proteins are cleaved, including the membrane stubs of transferrin receptor 1, the British dementia protein 2 and neuroregulin 1 following the shedding of the ectodomain mediated by other peptidases such as ADAM-10 and BACE-1 (Zahn et al., 2013, Martin et al., 2008, Fleck et al., 2016).
Domain architecture
MEROPS Classification
Classification Clan AD >> Subclan (none) >> Family A22 >> Subfamily B >> A22.004
Holotypesignal peptide peptidase-like protein 2B (Homo sapiens), Uniprot accession Q8TCT7 (peptidase unit: 155-513), MERNUM MER0019715
History Identifier created: MEROPS 6.0 (30 August 2002)
Catalytic typeAspartic
NC-IUBMBNot yet included in IUBMB recommendations.
Activity statushuman: putative (Grigorenko et al., 2002)
mouse: putative
Other databases TREEFAM
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
SPPL2B 19p13.3 ENSG00000005206 56928 608239
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
3110056O03Rik 10:C1 ENSMUSG00000035206 73218 MGI:1920468