Summary for peptidase A22.007: signal peptide peptidase-like protein 2A

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors


MEROPS Namesignal peptide peptidase-like protein 2A
Other namesIMP3, impas 3 peptidase, intramembrane protease 3, Mername-AA138 putative peptidase, RIKEN cDNA 2010106G01 (Mus musculus), PSH5, presenilin homologue-5, SPPL2A g.p. (Homo sapiens)
Name and HistorySignal peptide peptidase-like 2a is an intramembrane peptidase that performs regulated intramembrane proteolysis, particularly on single pass type II transmembrane proteins (Behnke et al., 2011).
Domain architecture
MEROPS Classification
Classification Clan AD >> Subclan (none) >> Family A22 >> Subfamily B >> A22.007
Holotypesignal peptide peptidase-like protein 2A (Homo sapiens), Uniprot accession Q8TCT8 (peptidase unit: 136-520), MERNUM MER0019711
History Identifier created: MEROPS 6.0 (30 August 2002)
Catalytic typeAspartic
NC-IUBMBNot yet included in IUBMB recommendations.
Activity statushuman: putative (Grigorenko et al., 2002)
mouse: putative
SpecificitySPPL2a cleaves the N-terminal fragment of the invariant chain, and is essential for B-cell development (Beisner et al., 2013). The membrane stump, following shedding of the ectodomain, of frontotemporal lobar degeneration risk factor TMEM106B is also a substrate (Brady et al., 2014).
LocationSPPL2a is predominantly localized to late endosomes and lysosomes because of a C-terminal tyrosine motif (Behnke et al., 2011).
Other databases TREEFAM
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
SPPL2A 15q21.2 ENSG00000138600 84888 608238
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
2010106G01Rik 2:F3 ENSMUSG00000027366 66552 MGI:1913802