Summary for peptidase A22.010: hop-1 peptidase

Summary Alignment Sequences Sequence features Distribution Literature


MEROPS Namehop-1 peptidase
Name and HistoryThe Hop-1 protein from Caenorhabditis elegans is an intramembrane, aspartic endopeptidase. Hop-1 and Sel-12 are homologues of chordate presenilins. Hop-1 can rescue the egg-laying defects caused by mutations in the Sel-12 gene (Li & Greenwald, 1997).
Domain architecture
MEROPS Classification
Classification Clan AD >> Subclan (none) >> Family A22 >> Subfamily A >> A22.010
Holotypehop-1 peptidase (Caenorhabditis elegans), Uniprot accession O02100 (peptidase unit: 1-358), MERNUM MER0005226
History Identifier created: MEROPS 6.4 (24 September 2003)
Catalytic typeAspartic
NC-IUBMBNot yet included in IUBMB recommendations.