Summary for peptidase A22.012: SPE-4 peptidase

Summary Alignment Tree Sequences Sequence features Distribution Literature


MEROPS NameSPE-4 peptidase
Name and HistorySPE-4 peptidase is an intramembrane, aspartic endopeptidase characterized from Caenorhabditis elegans.
Domain architecture
MEROPS Classification
Classification Clan AD >> Subclan (none) >> Family A22 >> Subfamily A >> A22.012
HolotypeSPE-4 peptidase (Caenorhabditis elegans), Uniprot accession Q01608 (peptidase unit: 1-465), MERNUM MER0005240
History Identifier created: MEROPS 7.5 (14 July 2006)
Catalytic typeAspartic
NC-IUBMBNot yet included in IUBMB recommendations.
SpecificitySwapping the active site domain of presenilin 1 with SPE-4 resulted in a protein that could process the beta-amyloid protein precursor but not Notch, and the difference in substrate recognition was shown by site-directed mutagenesis to depend on the nature of a residue in the GxGD motif that includes the active site aspartic acid (Yamasaki et al., 2006).
PhysiologySPE-4 is essential for the activation of sperm cells, and in a naturally occurring mutant known as hc196, spermatocytes are defective, and spermatids are activated prematurely (Gosney et al., 2008).