Summary for peptidase A28.004: skin SASPase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

 

Names
MEROPS Nameskin SASPase
Other namesASPRV1 g.p. (Homo sapiens), Taps putative peptidase, skin aspartic protease
Domain architecture
MEROPS Classification
Classification Clan AA >> Subclan (none) >> Family A28 >> Subfamily B >> A28.004
Holotypeskin SASPase (Mus musculus), Uniprot accession Q09PK2 (peptidase unit: 189-324), MERNUM MER0057496
History Identifier created: MEROPS 9.13 (6 July 2015)
Activity
Catalytic typeAspartic
NC-IUBMBNot yet included in IUBMB recommendations.
Other databases TREEFAMhttp://www.treefam.org/family/TF337956
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternSv/F/La/YScissile bondQls/Vlm/sg/T (based on 15 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 0 0 0 0 2 1
Pro 0 0 0 0 0 0 0 0
Ala 0 1 3 1 1 0 0 1
Val 3 0 1 0 0 9 1 0
Leu 1 1 10 1 3 3 0 1
Ile 0 0 0 0 0 1 0 0
Met 0 0 0 0 0 2 0 0
Phe 1 10 0 0 0 0 0 0
Tyr 0 0 0 9 1 0 1 0
Trp 0 0 0 0 0 0 0 0
Ser 8 0 0 0 2 0 8 0
Thr 0 0 0 0 0 0 0 8
Cys 0 0 0 0 0 0 1 1
Asn 0 0 0 2 0 0 0 0
Gln 0 0 0 0 8 0 0 0
Asp 0 1 0 0 0 0 0 0
Glu 1 1 1 2 0 0 1 1
Lys 0 1 0 0 0 0 1 1
Arg 0 0 0 0 0 0 0 0
His 1 0 0 0 0 0 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
ASPRV1 2p13.3 ENSG00000179818 151516 611765
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Asprv1 6:D1 ENSMUSG00000033508 67855 MGI:1915105