Summary for peptidase C01.006: ficin

Summary Alignment Sequences Sequence features Distribution Literature Substrates Inhibitors

 

Names
MEROPS Nameficin
Other namesficain, ficin E
MEROPS Classification
Classification Clan CA >> Subclan (none) >> Family C1 >> Subfamily A >> C01.006
Holotypeficin (Ficus glabrata) (peptidase unit: 1-12), MERNUM MER0001982
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeCysteine
PeplistIncluded in the Peplist with identifier PL00051
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.3
EnzymologyBRENDA database
BiotechnologyLaboratory reagent in blood group determination.
Pharmaceutical relevancePotential use for elimination of gastrointestinal parasites.
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/Ficain
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/fl/rScissile bond-/-/-/- (based on 15 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 1 2 1 0 0 0 1
Pro 1 0 0 0 0 0 1 2
Ala 0 1 0 0 0 0 1 0
Val 0 1 2 0 0 1 1 1
Leu 2 1 3 1 2 2 1 0
Ile 0 1 0 0 0 0 0 0
Met 0 0 0 0 0 0 0 0
Phe 0 2 4 2 1 0 0 0
Tyr 0 0 0 1 1 1 0 0
Trp 0 0 0 0 0 0 0 0
Ser 1 0 0 2 2 0 1 0
Thr 0 1 1 0 1 2 1 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 1 0 1
Gln 0 0 0 0 0 0 0 0
Asp 0 0 0 0 0 0 0 1
Glu 2 0 0 0 0 0 1 2
Lys 1 0 1 2 1 1 1 1
Arg 1 1 0 5 0 0 0 0
His 1 1 0 1 1 1 0 0