Summary for peptidase C01.007: actinidin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Nameactinidin
Other namesActinidia anionic protease, actinidain, protease B (freesia)
Domain architecture
MEROPS Classification
Classification Clan CA >> Subclan (none) >> Family C1 >> Subfamily A >> C01.007
Holotypeactinidin (Actinidia deliciosa), Uniprot accession P00785 (peptidase unit: 127-344), MERNUM MER0000648
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeCysteine
PeplistIncluded in the Peplist with identifier PL00052
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.14
EnzymologyBRENDA database
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/Actinidain
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/g/-/-Scissile bond-/-/g/p (based on 19 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 3 5 0 5 3 1 4 1
Pro 1 2 0 0 0 3 1 5
Ala 2 2 2 2 0 2 0 2
Val 0 0 2 1 3 2 1 1
Leu 0 1 2 0 3 0 3 1
Ile 0 0 0 0 0 0 0 0
Met 0 0 1 0 0 1 0 0
Phe 0 2 3 2 0 3 2 0
Tyr 0 0 1 2 1 0 0 2
Trp 0 0 0 0 0 0 0 0
Ser 2 1 2 0 1 0 0 0
Thr 0 0 0 0 1 1 0 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 1 0 0 0 0
Gln 0 0 0 1 1 0 0 0
Asp 0 0 1 0 1 0 1 1
Glu 1 0 1 1 1 0 1 0
Lys 1 1 0 1 0 0 1 1
Arg 1 0 0 2 0 0 0 0
His 1 1 0 1 0 2 0 0