Summary for peptidase C01.009: cathepsin V

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Substrates Inhibitors Pharma

 

Names
MEROPS Namecathepsin V
Other namescathepsin L2 (Homo sapiens), cathepsin U, CTSL2 g.p. (Homo sapiens)
Domain architecture
MEROPS Classification
Classification Clan CA >> Subclan (none) >> Family C1 >> Subfamily A >> C01.009
Holotypecathepsin V (Homo sapiens), Uniprot accession O60911 (peptidase unit: 113-334), MERNUM MER0004437
History Identifier created: MEROPS 3.03 (10 September 1998)
Activity
Catalytic typeCysteine
PeplistIncluded in the Peplist with identifier PL00053
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.43
EnzymologyBRENDA database
Proteolytic eventsCutDB database (3 cleavages)
Pharmaceutical relevanceThe activity of cathepsin V in degradation of the invariant chain of the MHC Class II complex, and its concentration in human thymic epithelial cells, suggest potential involvement in the immunopathogenesis of myasthenia gravis (Tolosa et al., 2003).
Pathways KEGGLysosome
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/Cathepsin_L2
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/lfv/rScissile bondk/r/y/g (based on 14 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 3 3 0 0 0 0 0 4
Pro 1 2 0 0 0 0 1 0
Ala 0 0 0 2 0 0 1 1
Val 1 1 2 1 0 0 0 1
Leu 0 1 6 1 1 1 0 1
Ile 0 1 0 0 0 0 0 0
Met 0 0 0 1 0 0 0 0
Phe 0 1 4 1 0 1 1 0
Tyr 0 0 0 0 0 0 4 0
Trp 0 0 0 0 0 0 0 0
Ser 1 0 0 1 0 0 0 0
Thr 0 0 0 0 1 0 0 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 0 0 0
Gln 0 0 0 1 0 0 1 0
Asp 0 0 0 0 0 0 0 1
Glu 1 1 0 0 1 1 0 1
Lys 1 0 1 1 5 1 1 0
Arg 0 0 1 5 1 5 0 0
His 1 0 0 0 0 0 0 0
Specificity from combinatorial peptides
 
Organism comment P4 P3 P2 P1 P1' P2' P3' P4' optimal substrate fluorophore or acceptor-donor pair Reference
Homo sapiens recombinant - A/G/H L R V I/V - - xALR+VIxx Abz-EDDnp Puzer et al., 2004
Homo sapiens recombinant H/broad n/P W/Y/L/F R/K - - - - HnWR ACC Choe et al., 2006
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
CTSL2 9q22.2 ENSG00000136943 1515 CTSL2 603308