Summary for peptidase C01.018: cathepsin F

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma


MEROPS Namecathepsin F
Other namesCLN13 (Homo sapiens)
Domain architecture
MEROPS Classification
Classification Clan CA >> Subclan (none) >> Family C1 >> Subfamily A >> C01.018
Holotypecathepsin F (Homo sapiens), Uniprot accession Q9UBX1 (peptidase unit: 270-484), MERNUM MER0004980
History Identifier created: MEROPS 4.0 (27 January 2000)
Catalytic typeCysteine
PeplistIncluded in the Peplist with identifier PL00057
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase
EnzymologyBRENDA database
Activity statushuman: active (Bromme, 2004)
mouse: active (by similarity) (Deussing et al., 2000)
Pharmaceutical relevanceCathepsin F is suggested to play a regulatory role in processing the invariant chain that is associated with MHC class II, and inhibiting cathepsin F activity may block MHC class II processing in macrophages (Somoza et al., 2002).
Pathways KEGGLysosome
Other databases WIKIPEDIA
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
CTSF 11q13.1-q13.3 ENSG00000174080 8722 CTSF 603539
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Ctsf 19:A ENSMUSG00000006458 56464 MGI:1861434