Summary for peptidase C01.018: cathepsin F

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namecathepsin F
Other namesCLN13 (Homo sapiens)
Domain architecture
MEROPS Classification
Classification Clan CA >> Subclan (none) >> Family C1 >> Subfamily A >> C01.018
Holotypecathepsin F (Homo sapiens), Uniprot accession Q9UBX1 (peptidase unit: 270-484), MERNUM MER0004980
History Identifier created: MEROPS 4.0 (27 January 2000)
Activity
Catalytic typeCysteine
PeplistIncluded in the Peplist with identifier PL00057
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.41
EnzymologyBRENDA database
Activity statushuman: active (Bromme, 2004)
mouse: active (by similarity) (Deussing et al., 2000)
Pharmaceutical relevanceCathepsin F is suggested to play a regulatory role in processing the invariant chain that is associated with MHC class II, and inhibiting cathepsin F activity may block MHC class II processing in macrophages (Somoza et al., 2002).
Pathways KEGGLysosome
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/CTSF
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
CTSF 11q13.1-q13.3 ENSG00000174080 8722 CTSF 603539
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Ctsf 19:A ENSMUSG00000006458 56464 MGI:1861434