Summary for peptidase C01.033: cathepsin L1 (Fasciola sp.)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Namecathepsin L1 (Fasciola sp.)
Other namesCL1, FheCL1, FhPcW1 (Fasciola hepatica)
Domain architecture
MEROPS Classification
Classification Clan CA >> Subclan (none) >> Family C1 >> Subfamily A >> C01.033
Holotypecathepsin L1 (Fasciola sp.) (Fasciola gigantica) (peptidase unit: 107-323), MERNUM MER0002418
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeCysteine
PeplistIncluded in the Peplist with identifier PL00061
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (180 cleavages)
PhysiologyNutrition of organism.
Pharmaceutical relevancePotential drug target for liver fluke infection. Detection of antibodies has value in diagnosis of infection.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/-Scissile bond-/-/-/- (based on 196 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 14 12 8 17 15 13 14 15
Pro 11 8 12 7 8 11 14 11
Ala 22 22 23 23 25 21 20 23
Val 17 14 26 14 14 21 15 24
Leu 18 20 37 24 25 19 27 25
Ile 1 1 0 0 0 1 0 1
Met 2 4 3 3 4 2 0 1
Phe 11 12 16 7 7 12 11 10
Tyr 4 2 1 3 4 3 5 3
Trp 0 1 3 3 2 1 3 2
Ser 11 8 10 16 11 11 11 12
Thr 10 10 13 12 12 8 11 10
Cys 2 3 3 0 5 4 3 2
Asn 8 8 6 8 11 6 9 7
Gln 2 5 0 2 1 3 2 3
Asp 15 14 7 9 9 12 8 13
Glu 11 9 8 10 9 10 6 7
Lys 11 16 12 14 13 13 16 8
Arg 4 6 2 11 4 7 4 2
His 13 12 5 12 11 12 11 11