Summary for peptidase C01.040: cathepsin H

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namecathepsin H
Other namesbenzoylarginine-naphthylamide (BANA) hydrolase, cathepsin B3, CTSH g.p. (Homo sapiens), lysosomal arginyl aminopeptidase
Domain architecture
MEROPS Classification
Classification Clan CA >> Subclan (none) >> Family C1 >> Subfamily A >> C01.040
Holotypecathepsin H (Homo sapiens), Uniprot accession P09668 (peptidase unit: 115-334), MERNUM MER0000629
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeCysteine
PeplistIncluded in the Peplist with identifier PL00064
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.16
EnzymologyBRENDA database
Proteolytic eventsCutDB database (10 cleavages)
Activity statushuman: active (Kirschke, 2004)
mouse: active (by similarity to rat) (Kirschke et al., 1977)
PhysiologyContributes to lysosomal proteolysis, and antigen processing. Suggested to be involved in the processing of pulmonary surfactant proteins B and C, and lamellar body genesis (Guttentag et al., 2003). May contribute to the transformation of LDL to an atherogenic moiety (Han et al., 2003).
Pathways KEGGLysosome
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/Cathepsin_H
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/-Scissile bond-/-/-/- (based on 48 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 3 2 3 5 2 2 2 3
Pro 2 2 4 3 1 9 2 3
Ala 2 1 1 3 3 0 1 2
Val 3 3 6 3 2 2 4 3
Leu 2 3 3 4 2 2 1 2
Ile 0 1 2 3 5 2 3 3
Met 1 1 1 2 1 2 2 0
Phe 2 4 3 3 2 1 3 2
Tyr 1 0 0 1 1 0 0 0
Trp 0 1 0 0 1 0 0 0
Ser 3 0 3 6 8 3 5 1
Thr 1 1 2 1 4 5 1 1
Cys 0 2 0 0 0 0 0 0
Asn 3 2 0 1 2 2 1 1
Gln 5 3 3 1 1 1 3 2
Asp 0 0 0 0 1 1 1 2
Glu 0 4 3 1 1 4 1 1
Lys 2 2 1 4 3 1 2 2
Arg 1 0 0 6 2 1 1 3
His 0 0 0 1 0 0 1 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
CTSH 15q24-q25 ENSG00000103811 1512 CTSH 116820
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Ctsh 9:E3.1 ENSMUSG00000032359 13036 MGI:107285