Summary for peptidase C01.073: peptidase 1 (mite)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Namepeptidase 1 (mite)
Other namesallergen Der f 1 (Dermatophagoides farinae), antigen Der p 1 (Dermatophagoides pteronyssinus), antigen Eur m 1 (Euroglyphus maynei), antigen Pso o 1 (Psoroptes ovis)
Domain architecture
MEROPS Classification
Classification Clan CA >> Subclan (none) >> Family C1 >> Subfamily A >> C01.073
Holotypepeptidase 1 (mite) (Dermatophagoides pteronyssinus), Uniprot accession P08176 (peptidase unit: 99-320), MERNUM MER0000719
History Identifier created: MEROPS 3.02 (25 June 1998)
Activity
Catalytic typeCysteine
PeplistIncluded in the Peplist with identifier PL00069
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.65
EnzymologyBRENDA database
Proteolytic eventsCutDB database (13 cleavages)
PhysiologyAllergen, and IgE destruction: role in asthma.
Pharmaceutical relevancePotential drug target for asthma. Its enzymatic activity has been shown to have pro-inflammatory effects that could also negatively influence efficacy of allergen-specific immunotherapy. The cytokine release induced by this allergen in respiratory epithelial cells is, in part, mediated by activation of protease-activated receptor-2 (Asokananthan et al., 2002).
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/ag/-Scissile bond-/-/-/l (based on 29 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 3 3 6 4 3 5 4 2
Pro 4 0 0 0 0 3 3 5
Ala 3 0 7 5 2 2 0 0
Val 3 3 3 0 3 3 0 1
Leu 4 2 3 2 4 1 3 7
Ile 0 0 0 0 2 1 1 0
Met 1 0 0 0 0 1 1 1
Phe 2 3 1 1 3 0 1 0
Tyr 0 0 3 1 0 0 0 0
Trp 0 1 0 0 0 0 0 0
Ser 2 1 2 1 5 5 6 4
Thr 1 1 2 1 3 1 1 2
Cys 0 0 0 0 0 0 0 0
Asn 0 2 0 1 1 2 0 1
Gln 1 3 0 2 0 0 1 0
Asp 2 2 0 2 0 0 0 0
Glu 0 1 2 4 0 2 3 2
Lys 0 6 0 2 1 0 0 1
Arg 1 1 0 3 0 1 2 0
His 0 0 0 0 0 0 1 1