Summary for peptidase C01.074: CPB peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

 

Names
MEROPS NameCPB peptidase
Other namesCPB protease, lmcpb g.p. (Leishmania mexicana), lmajl g.p. (Leishmani major), lpcys2 g.p. (Leishmania pifanoi)
Domain architecture
MEROPS Classification
Classification Clan CA >> Subclan (none) >> Family C1 >> Subfamily A >> C01.074
HolotypeCPB peptidase (Leishmania mexicana), Uniprot accession P36400 (peptidase unit: 125-341), MERNUM MER0000668
History Identifier created: MEROPS 5.61 (29 October 2001)
Activity
Catalytic typeCysteine
PeplistIncluded in the Peplist with identifier PL00070
NC-IUBMBNot yet included in IUBMB recommendations.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/K/L/RScissile bondF/S/K/Q (based on 17 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 0 0 0 0 0 0
Pro 0 0 0 0 0 1 1 0
Ala 0 1 0 0 2 1 1 0
Val 0 0 0 0 0 0 0 0
Leu 0 0 16 0 1 0 0 0
Ile 0 0 0 0 0 0 0 0
Met 0 0 0 0 0 0 0 0
Phe 0 1 1 0 14 1 0 0
Tyr 0 0 0 0 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 0 0 0 0 0 12 0 0
Thr 0 0 0 0 0 0 0 0
Cys 0 0 0 1 0 0 0 0
Asn 0 0 0 0 0 0 0 0
Gln 0 0 0 0 0 0 0 16
Asp 0 0 0 0 0 0 0 0
Glu 0 0 0 0 0 0 0 0
Lys 0 13 0 1 0 0 13 0
Arg 0 1 0 14 0 1 1 0
His 0 0 0 1 0 0 0 0
Specificity from combinatorial peptides
 
Organism comment P4 P3 P2 P1 P1' P2' P3' P4' optimal substrate fluorophore or acceptor-donor pair Reference
Leishmania mexicana recombinant - - - Iaf/Amf - - - - xxxIaf+xxxx Abz-EDDnp Alves et al., 2001
Leishmania mexicana recombinant E/K/P R/K L R/K R R R K ERLR+RRRK Tyr(NO2)-Abz St Hilaire et al., 2000
Leishmania mexicana recombinant P/H K L R - - - - PKLR ACC Choe et al., 2006