Summary for peptidase C01.084: bleomycin hydrolase (animal)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors

 

Names
MEROPS Namebleomycin hydrolase (animal)
Other namesaminopeptidase H, hydrolase H, BANA-hydrolase, BLH, BLMH g.p. (Homo sapiens)
Domain architecture
MEROPS Classification
Classification Clan CA >> Subclan (none) >> Family C1 >> Subfamily B >> C01.084
Holotypebleomycin hydrolase (animal) (Homo sapiens), Uniprot accession Q13867 (peptidase unit: 3-443), MERNUM MER0002481
History Identifier created: MEROPS 3.02 (25 June 1998)
Activity
Catalytic typeCysteine
PeplistIncluded in the Peplist with identifier PL00073
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.40
EnzymologyBRENDA database
Activity statushuman: active (Joshua-Tor & Johnston, 2004)
mouse: active (Haston et al., 2002)
PhysiologyCytosolic aminopeptidase. Suggested to function as an MHC class I epitope-processing protease (Haston et al., 2002).
KnockoutA mouse line deficient in bleomycin hydrolase has been created, and showed that the enzyme has an important role in neonatal survival and in maintaining epidermal integrity (Schwartz et al., 1999).
Pharmaceutical relevancePeptidase destroys chemotherapeutic bleomycin.
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/BLMH
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternek/vl/hv/-Scissile bondfq/ka/le/vd (based on 19 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 0 0 1 0 0 0
Pro 0 0 0 0 0 0 0 0
Ala 0 0 0 1 0 2 1 0
Val 0 3 2 1 0 0 0 3
Leu 0 2 1 3 0 0 3 0
Ile 0 0 0 0 0 0 0 0
Met 0 0 0 1 0 0 0 0
Phe 0 0 0 2 3 1 0 0
Tyr 0 0 0 0 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 0 0 0 0 0 0 0 0
Thr 0 0 0 0 0 0 0 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 1 0 0 0 0
Gln 1 0 0 0 3 0 0 0
Asp 0 0 0 0 0 0 0 2
Glu 3 0 0 1 0 0 2 1
Lys 2 1 0 0 0 3 0 0
Arg 0 0 0 3 0 0 0 0
His 0 0 3 4 0 0 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
BLMH 17q11.1-q11.2 ENSG00000108578 642 BLMH 602403
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Blmh 11:B5 ENSMUSG00000020840 23826 MGI:1345186