Summary for peptidase C01.101: cathepsin B-like peptidase, nematode

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Namecathepsin B-like peptidase, nematode
Other namesAc-CP-1 (Ancylostoma caninum), Ac-CP-2 (Ancylostoma caninum), acey-1 (Ancylostoma ceylanicum), AC-2 (Haemonchus contortus), AC-3 (Haemonchus contortus), AC-4 (Haemonchus contortus), AC-5 (Haemonchus contortus)
Domain architecture
MEROPS Classification
Classification Clan CA >> Subclan (none) >> Family C1 >> Subfamily A >> C01.101
Holotypecathepsin B-like peptidase, nematode (Haemonchus contortus), Uniprot accession P19092 (peptidase unit: 78-338), MERNUM MER0000701
History Identifier created: MEROPS 5.61 (29 October 2001)
Activity
Catalytic typeCysteine
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (45 cleavages)
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/-Scissile bond-/-/-/- (based on 47 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 2 1 2 4 3 1 3 4
Pro 3 2 0 2 4 5 3 2
Ala 11 5 3 5 5 2 5 3
Val 1 10 3 2 3 6 3 7
Leu 6 6 10 7 7 10 3 2
Ile 1 2 2 0 0 0 1 1
Met 0 0 2 0 0 0 2 0
Phe 2 3 2 4 1 4 5 5
Tyr 1 0 2 2 1 0 0 0
Trp 0 1 1 1 1 4 2 0
Ser 3 2 2 5 3 2 2 0
Thr 1 2 3 2 2 3 5 3
Cys 2 0 2 1 1 0 0 2
Asn 6 0 2 2 2 1 2 1
Gln 0 0 0 2 1 0 1 1
Asp 1 2 1 3 1 2 4 4
Glu 1 3 1 1 3 2 0 1
Lys 1 4 6 0 3 1 2 8
Arg 2 0 1 3 3 3 0 1
His 3 4 2 1 3 1 4 2