Summary for peptidase C03.001: poliovirus-type picornain 3C

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

 

Names
MEROPS Namepoliovirus-type picornain 3C
Other namespicornavirus endopeptidase 3C, picornavirus peptidase 3C (poliovirus), picornain 3C (poliovirus), protein 3CD
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(C) >> Family C3 >> Subfamily A >> C03.001
Holotypepoliovirus-type picornain 3C (human poliovirus 1), Uniprot accession P03299 (peptidase unit: 1564-1745), MERNUM MER0000748
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeCysteine
PeplistIncluded in the Peplist with identifier PL00081
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.28
EnzymologyBRENDA database
Proteolytic eventsCutDB database (13 cleavages)
PhysiologyViral polyprotein processing in replication. Cleaves some host transcription factors and microtubule-associated protein 4.
Pharmaceutical relevanceA potential target for antiviral drugs.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternav/-/-/QScissile bondG/-/-/- (based on 14 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 1 0 0 13 0 2 0
Pro 1 0 1 0 0 3 3 2
Ala 7 0 3 0 0 2 0 0
Val 2 0 2 0 0 1 1 2
Leu 1 3 2 0 0 2 1 0
Ile 1 2 0 0 0 2 1 0
Met 0 1 0 0 0 0 0 0
Phe 0 0 1 0 0 0 0 1
Tyr 0 0 0 0 0 0 1 0
Trp 1 0 0 0 0 0 0 1
Ser 0 0 1 0 0 0 1 1
Thr 1 1 0 0 1 0 1 1
Cys 0 1 0 0 0 0 0 0
Asn 0 0 1 0 0 0 1 1
Gln 0 2 0 14 0 2 0 3
Asp 0 0 0 0 0 1 0 0
Glu 0 0 1 0 0 1 1 0
Lys 0 1 1 0 0 0 0 0
Arg 0 1 0 0 0 0 1 2
His 0 1 1 0 0 0 0 0