Summary for peptidase C03.020: enterovirus picornain 2A

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Nameenterovirus picornain 2A
Other namesCoxsackievirus-type picornain 2A, enterovirus 71 picornain 2A, human hand, foot and mouth disease virus 2A peptidase, picornavirus endopeptidase 2A, picornavirus peptidase 2A (poliovirus), poliovirus-type picornain 2A, poliovirus protease 2A, picornain 2A (poliovirus), swine vesicular disease virus picornain 2A
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(C) >> Family C3 >> Subfamily B >> C03.020
Holotypeenterovirus picornain 2A (human poliovirus 1), Uniprot accession P03299 (peptidase unit: 882-1030), MERNUM MER0000766
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeCysteine
PeplistIncluded in the Peplist with identifier PL00085
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.29
EnzymologyBRENDA database
Proteolytic eventsCutDB database (4 cleavages)
PhysiologyViral polyprotein processing in replication. Cleavage of host eIF-4G.
Pathways KEGGViral myocarditis
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternLm/-/Tn/-Scissile bondG/pa/r/- (based on 12 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 2 1 0 11 0 2 2
Pro 1 0 1 0 0 4 2 2
Ala 0 0 0 0 0 3 0 2
Val 1 0 0 1 0 1 0 0
Leu 7 1 0 0 0 0 0 2
Ile 0 1 0 1 0 0 0 0
Met 2 1 0 2 0 0 0 0
Phe 0 0 0 0 0 1 1 0
Tyr 0 0 0 2 0 0 1 0
Trp 0 0 0 0 0 0 0 0
Ser 0 3 0 1 0 1 2 0
Thr 1 3 7 3 0 1 0 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 2 0 0 0 0 0
Gln 0 1 1 0 0 0 0 0
Asp 0 0 0 0 0 0 0 0
Glu 0 0 0 0 0 0 0 0
Lys 0 0 0 0 0 0 0 0
Arg 0 0 0 2 0 0 3 2
His 0 0 0 0 0 0 0 1