Summary for peptidase C03.021: rhinovirus picornain 2A

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Namerhinovirus picornain 2A
Other nameshuman rhinovirus protease 2A, picornain 2A (human rhinovirus)
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(C) >> Family C3 >> Subfamily B >> C03.021
Holotyperhinovirus picornain 2A (human rhinovirus 2), Uniprot accession P04936 (peptidase unit: 849-996), MERNUM MER0000781
History Identifier created: MEROPS 3.02 (25 June 1998)
Activity
Catalytic typeCysteine
PeplistIncluded in the Peplist with identifier PL00086
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (6 cleavages)
PhysiologyViral polyprotein processing in replication.
Pharmaceutical relevancePotential drug target for human common cold.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternli/ts/t/aScissile bondG/pa/ps/- (based on 12 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 2 1 0 9 0 0 2
Pro 1 0 1 0 0 5 3 1
Ala 1 0 0 4 2 3 1 2
Val 2 0 0 1 1 1 1 0
Leu 4 1 0 1 0 0 0 2
Ile 3 0 0 0 0 0 0 0
Met 0 0 1 0 0 0 0 0
Phe 0 0 0 0 0 0 0 0
Tyr 0 0 0 1 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 1 3 2 1 0 1 3 0
Thr 0 4 5 2 0 0 2 1
Cys 0 0 0 0 0 0 0 0
Asn 0 0 2 0 0 1 0 0
Gln 0 0 0 0 0 0 0 1
Asp 0 1 0 0 0 0 0 1
Glu 0 0 0 0 0 0 0 0
Lys 0 1 0 0 0 0 0 0
Arg 0 0 0 2 0 0 2 2
His 0 0 0 0 0 1 0 0