Summary for peptidase C04.001: nuclear-inclusion-a peptidase (plum pox virus)

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

 

Names
MEROPS Namenuclear-inclusion-a peptidase (plum pox virus)
Other names48/49 kDa protease, protease nuclear inclusion a (NIa), Japanese yam virus NIa protease, plum pox virus NIa protease, potato virus A NIa protease, turnip mosaic virus NIa protease, VPg-protease
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(C) >> Family C4 >> Subfamily (none) >> C04.001
Holotypenuclear-inclusion-a peptidase (plum pox virus), Uniprot accession P13529 (peptidase unit: 2049-2293), MERNUM MER0001785
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeCysteine
PeplistIncluded in the Peplist with identifier PL00087
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.44
EnzymologyBRENDA database
Proteolytic eventsCutDB database (2 cleavages)
BiotechnologyHas found applications in protein expression vectors, conferring self-cleaving activity on the products.
PhysiologyPolyprotein processing in the viral replication.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternV/Y/H/QScissile bonda/la/-/- (based on 10 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 0 0 1 1 0 0
Pro 0 0 1 0 0 0 0 0
Ala 0 0 0 0 3 3 0 0
Val 7 0 0 0 0 0 1 1
Leu 1 0 0 0 0 4 0 0
Ile 0 0 0 0 0 0 1 0
Met 0 0 0 0 0 0 0 0
Phe 0 0 1 0 0 0 1 1
Tyr 0 8 0 0 0 0 0 0
Trp 0 0 0 0 1 1 0 0
Ser 1 0 0 1 2 0 0 1
Thr 0 0 0 1 2 0 1 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 1 0 0 0 1 0
Gln 0 1 0 8 0 0 0 0
Asp 0 0 0 0 0 0 0 0
Glu 0 0 0 0 0 0 0 1
Lys 1 0 0 0 1 0 0 1
Arg 0 0 0 0 0 0 0 0
His 0 1 7 0 0 0 0 0