Summary for peptidase C05.001: adenain

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Nameadenain
Other namesadenovirus endopeptidase, L3, p23
Domain architecture
MEROPS Classification
Classification Clan CE >> Subclan (none) >> Family C5 >> Subfamily (none) >> C05.001
Holotypeadenain (human adenovirus type 2), Uniprot accession P03252 (peptidase unit: 1-204), MERNUM MER0000802
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeCysteine
PeplistIncluded in the Peplist with identifier PL00089
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.39
EnzymologyBRENDA database
Proteolytic eventsCutDB database (15 cleavages)
PhysiologyCleaves scaffold and other proteins in adenoviral capsid maturation.
Pharmaceutical relevancePotential drug target for antiviral therapy.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternlmi/-/G/GScissile bondgai/-/-/- (based on 26 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 1 23 14 11 1 1 1
Pro 1 1 0 1 0 0 2 0
Ala 0 3 0 0 4 1 0 1
Val 2 3 0 0 1 4 1 3
Leu 10 1 0 3 0 3 1 1
Ile 5 0 0 1 3 0 0 0
Met 7 0 0 0 1 0 0 0
Phe 0 1 0 0 1 3 1 2
Tyr 0 0 0 0 0 0 1 0
Trp 0 1 0 0 0 1 0 3
Ser 0 4 3 0 1 1 2 4
Thr 0 1 0 0 0 0 1 0
Cys 0 0 0 0 0 0 0 0
Asn 0 1 0 1 1 0 2 0
Gln 1 0 0 0 0 0 3 0
Asp 0 0 0 1 0 0 0 1
Glu 0 1 0 0 0 1 0 1
Lys 0 1 0 0 0 2 3 0
Arg 0 1 0 2 0 3 1 3
His 0 0 0 0 0 0 1 0