Summary for peptidase C10.001: streptopain

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Namestreptopain
Other nameserythrotoxin B, erythrogenic toxin B, histase, interleukin 1 beta convertase, secreted cysteine proteinase, speB g.p. (Streptococcus pyogenes), streptococcal cysteine proteinase, Streptococcus peptidase A, Streptococcus pyogenes pyrogenic exotoxin B, SCP, SpeB
Domain architecture
MEROPS Classification
Classification Clan CA >> Subclan (none) >> Family C10 >> Subfamily (none) >> C10.001
Holotypestreptopain (Streptococcus pyogenes), Uniprot accession P00788 (peptidase unit: 146-398), MERNUM MER0001346
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeCysteine
PeplistIncluded in the Peplist with identifier PL00092
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.10
EnzymologyBRENDA database
Proteolytic eventsCutDB database (4 cleavages)
Pharmaceutical relevanceMay or may not be a drug target for management of streptococcal infection (Ashbaugh et al., 2001; Hytonen et al., 2001). Reported to be of diagnostic value for Streptococcus pyogenes infections (Batsford et al., 2002). Is pyrogenic exotoxin B.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patterna/-/iv/kScissile bond-/-/-/e (based on 27 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 1 0 0 4 5 3 2
Pro 0 0 1 0 0 3 2 0
Ala 6 4 0 3 3 1 5 1
Val 0 1 6 0 2 1 2 3
Leu 0 3 2 3 4 1 1 2
Ile 0 0 6 0 0 0 0 0
Met 0 0 1 0 0 0 0 0
Phe 0 2 3 3 1 0 0 0
Tyr 1 1 3 2 2 0 1 0
Trp 0 0 0 0 0 0 0 0
Ser 0 0 0 0 0 1 1 1
Thr 3 2 0 0 1 4 0 0
Cys 0 0 0 0 0 0 0 0
Asn 1 1 0 3 0 2 0 0
Gln 3 2 0 0 3 0 1 0
Asp 2 0 0 0 1 1 0 1
Glu 2 2 0 1 1 1 0 6
Lys 0 2 0 7 2 0 3 2
Arg 1 0 0 1 0 1 1 2
His 1 1 1 1 0 1 2 2