Summary for peptidase C12.003: ubiquitinyl hydrolase-L3

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Nameubiquitinyl hydrolase-L3
Other namesubiquitin C-terminal hydrolase UCH-L3 (mammal)
Domain architecture
MEROPS Classification
Classification Clan CA >> Subclan (none) >> Family C12 >> Subfamily (none) >> C12.003
Holotypeubiquitinyl hydrolase-L3 (Homo sapiens), Uniprot accession P15374 (peptidase unit: 4-230), MERNUM MER0000836
History Identifier created: MEROPS 3.02 (25 June 1998)
Activity
Catalytic typeCysteine
PeplistIncluded in the Peplist with identifier PL00095
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.19 (Omega peptidases) >> Peptidase 3.4.19.12
EnzymologyBRENDA database
Activity statushuman: active (Wilkinson, 2004)
mouse: active (by similarity to human) (Dang et al., 1998)
PhysiologyRecycling of ubiquitin in ubiquitin-dependent proteolysis.
KnockoutMice with a targeted mutation in ubiquitinyl hydrolase L3 were normal (Kurihara et al., 2000), but loss of ubiquitinyl hydrolase L3 together with ubiquitinyl hydrolase L1 (C12.001) led to neurodegeneration, posterior paralysis and dysphagia (Kurihara et al., 2001).
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/UCHL3
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternL/R/G/GScissile bondkim/-/-/- (based on 26 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 23 26 0 0 0 0
Pro 0 0 0 0 0 0 0 2
Ala 0 0 1 0 0 0 0 0
Val 1 0 1 0 0 0 0 0
Leu 19 0 0 0 0 0 0 0
Ile 0 0 0 0 2 2 2 0
Met 0 0 0 0 2 0 0 0
Phe 1 0 0 0 0 0 0 2
Tyr 1 1 0 0 0 0 0 0
Trp 1 1 0 0 0 0 0 0
Ser 0 0 0 0 0 0 0 0
Thr 0 0 0 0 0 0 0 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 0 0 0
Gln 0 0 0 0 0 2 0 0
Asp 0 0 0 0 1 0 0 0
Glu 0 0 0 0 0 0 2 0
Lys 1 1 0 0 5 0 0 0
Arg 1 23 0 0 0 0 0 0
His 0 0 0 0 1 0 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
UCHL3 13q21.2-q22.1 ENSG00000118939 7347 UCHL3 603090
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Uchl3 14:E2 ENSMUSG00000035337 50933 MGI:1355274