Summary for peptidase C14.005: caspase-6

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namecaspase-6
Other namesMch2
Domain architecture
MEROPS Classification
Classification Clan CD >> Subclan (none) >> Family C14 >> Subfamily A >> C14.005
Holotypecaspase-6 (Homo sapiens), Uniprot accession P55212 (peptidase unit: 9-292), MERNUM MER0002708
History Identifier created: MEROPS 3.02 (25 June 1998)
Activity
Catalytic typeCysteine
PeplistIncluded in the Peplist with identifier PL00102
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.59
EnzymologyBRENDA database
Proteolytic eventsCutDB database (173 cleavages)
Activity statushuman: active (Garcia-Calvo et al., 1999)
mouse: active (by similarity)
Pharmaceutical relevanceProposed as effector for a tumor-cell-killing system (Komata et al., 2001).
Pathways KEGGApoptosis
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/Caspase_6
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/e/-/DScissile bondgsa/-/-/- (based on 1307 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 25 34 29 0 464 78 108 119
Pro 27 8 52 0 12 11 139 112
Ala 74 67 62 0 195 173 111 119
Val 231 66 183 0 34 236 95 69
Leu 99 46 151 0 24 157 93 89
Ile 71 21 78 0 7 74 47 46
Met 20 16 48 0 23 31 21 11
Phe 14 18 32 0 37 79 28 19
Tyr 13 14 41 0 23 51 18 15
Trp 2 0 11 0 7 10 8 9
Ser 93 84 80 0 344 120 154 151
Thr 145 45 142 0 20 60 80 65
Cys 17 22 23 0 13 16 22 25
Asn 29 26 45 0 13 20 60 33
Gln 34 94 32 0 8 32 50 62
Asp 121 148 55 1307 26 38 82 111
Glu 154 465 135 0 27 69 108 178
Lys 2 3 10 0 13 23 43 28
Arg 1 3 6 0 7 14 21 19
His 12 17 15 0 9 14 16 24
Specificity from combinatorial peptides
 
Organism comment P4 P3 P2 P1 P1' P2' P3' P4' optimal substrate fluorophore or acceptor-donor pair Reference
Homo sapiens recombinant V/T - - D G - - - VxxD+Gxxx Abz-Tyr(NO2) Stennicke et al., 2000
Homo sapiens recombinant V/T/I E H/V/I D - - - - VEHD AMC Thornberry et al., 1997
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
CASP6 4q25 ENSG00000138794 839 CASP6 601532
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Casp6 3:H1 ENSMUSG00000027997 12368 MGI:1312921