Summary for peptidase C14.006: caspase-2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namecaspase-2
Other namescaspase-2L, caspase-2S, Ich-1, NEDD-2
Domain architecture
MEROPS Classification
Classification Clan CD >> Subclan (none) >> Family C14 >> Subfamily A >> C14.006
Holotypecaspase-2 (Mus musculus), Uniprot accession P29594 (peptidase unit: 167-449), MERNUM MER0000855
History Identifier created: MEROPS 3.02 (25 June 1998)
Activity
Catalytic typeCysteine
PeplistIncluded in the Peplist with identifier PL00430
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.55
EnzymologyBRENDA database
Proteolytic eventsCutDB database (3 cleavages)
Activity statushuman: active (Garcia-Calvo et al., 1999)
mouse: active (by similarity) (Troy et al., 2003)
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/Caspase_2
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternd/e/-/DScissile bondGsa/-/-/- (based on 290 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 4 12 11 0 149 23 28 32
Pro 3 7 27 0 0 3 35 28
Ala 13 19 25 0 44 38 20 33
Val 18 17 36 0 5 53 19 14
Leu 20 18 29 0 2 40 28 13
Ile 7 6 6 0 0 15 9 8
Met 4 3 10 0 6 6 7 4
Phe 3 5 4 0 4 14 6 4
Tyr 3 4 6 0 2 17 4 3
Trp 1 0 1 0 1 2 2 0
Ser 19 26 31 0 66 18 35 40
Thr 12 16 33 0 1 15 23 13
Cys 3 2 6 0 3 5 5 7
Asn 4 7 8 0 2 7 11 8
Gln 4 18 9 0 1 8 9 16
Asp 80 11 3 290 0 3 13 24
Glu 31 60 10 0 1 10 13 29
Lys 0 0 0 0 0 5 10 7
Arg 0 0 0 0 1 2 5 1
His 0 5 6 0 1 5 7 5
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
CASP2 7q34-q35 ENSG00000106144 835 CASP2 600639
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Casp2 6:B2 ENSMUSG00000029863 12366 MGI:97295