Summary for peptidase C14.010: caspase-9

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namecaspase-9
Other namesICE-LAP6, Mch6
Domain architecture
MEROPS Classification
Classification Clan CD >> Subclan (none) >> Family C14 >> Subfamily A >> C14.010
Holotypecaspase-9 (Homo sapiens), Uniprot accession P55211 (peptidase unit: 117-416), MERNUM MER0002707
History Identifier created: MEROPS 3.02 (25 June 1998)
Activity
Catalytic typeCysteine
PeplistIncluded in the Peplist with identifier PL00104
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.62
EnzymologyBRENDA database
Proteolytic eventsCutDB database (9 cleavages)
Activity statushuman: active (Garcia-Calvo et al., 1999)
mouse: active (Fujita et al., 2001)
PhysiologyOne of the "initator" caspases in mammalian cell apoptosis, activating caspase-3.
KnockoutThe majority of caspase-9 knockout mice die perinatally with a markedly enlarged and malformed cerebrum caused by reduced apoptosis during brain development (Kuida et al., 1998).
Pharmaceutical relevanceInoue et al. (2003) suggest that caspase-9 plays a crucial role in the disease progression of amyotrophic lateral sclerosis, and constitutes a promising therapeutic target.
Pathways KEGGAlzheimer's disease
KEGGAmyotrophic lateral sclerosis (ALS)
KEGGApoptosis
KEGGColorectal cancer
KEGGHepatitis B
KEGGHuntington's disease
KEGGInfluenza A
KEGGLegionellosis
KEGGp53 signaling pathway
KEGGParkinson's disease
KEGGPathways in cancer
KEGGSmall cell lung cancer
KEGGToxoplasmosis
KEGGTuberculosis
KEGGViral myocarditis
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/Caspase-9
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/ed/-/DScissile bond-/-/-/- (based on 14 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 0 0 3 1 3 1
Pro 2 0 2 0 0 1 2 1
Ala 0 0 0 0 2 1 1 0
Val 2 0 2 0 2 1 1 0
Leu 1 1 1 0 0 1 1 0
Ile 2 1 0 0 0 1 1 1
Met 1 0 0 0 1 0 1 1
Phe 0 0 1 0 0 0 0 1
Tyr 0 0 0 0 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 1 1 1 0 2 1 1 4
Thr 1 1 1 0 1 2 0 1
Cys 0 0 0 0 1 0 0 0
Asn 0 0 1 0 0 0 0 0
Gln 0 0 0 0 0 1 0 0
Asp 3 3 1 12 1 0 0 2
Glu 1 6 2 2 0 1 0 0
Lys 0 0 0 0 0 1 1 0
Arg 0 0 1 0 0 1 1 1
His 0 1 1 0 0 0 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
CASP9 1p36.1-p36.3 ENSG00000132906 842 CASP9 602234
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Casp9 4:E1 ENSMUSG00000028914 12371 MGI:1277950