Summary for peptidase C14.019: caspase DRONC (Drosophila melanogaster)-type peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Namecaspase DRONC (Drosophila melanogaster)-type peptidase
Other namescaspase Nc (Drosophila melanogaster), Nc protein (Drosophila melanogaster)
Domain architecture
MEROPS Classification
Classification Clan CD >> Subclan (none) >> Family C14 >> Subfamily A >> C14.019
Holotypecaspase DRONC (Drosophila melanogaster)-type peptidase, Uniprot accession Q9XYF4 (peptidase unit: 154-447), MERNUM MER0005247
History Identifier created: MEROPS 3.30 (20 July 1999)
Activity
Catalytic typeCysteine
PeplistIncluded in the Peplist with identifier PL00431
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (1 cleavage)
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternd/Eq/tv/DScissile bond-/-/-/- (based on 11 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 0 0 1 0 1 0
Pro 0 0 1 0 0 0 0 1
Ala 0 0 1 0 1 0 0 0
Val 2 1 2 0 0 0 0 0
Leu 0 0 0 0 0 1 0 0
Ile 2 0 1 0 0 0 0 0
Met 0 0 0 0 0 0 0 0
Phe 0 0 0 0 0 0 0 0
Tyr 1 0 0 0 0 0 0 0
Trp 1 0 0 0 0 0 0 0
Ser 0 0 0 0 0 0 1 2
Thr 2 0 5 0 1 0 0 0
Cys 0 0 0 0 0 1 0 0
Asn 0 0 0 0 0 0 0 0
Gln 0 2 0 0 0 0 0 0
Asp 3 0 0 9 0 1 0 0
Glu 0 7 0 2 0 0 0 0
Lys 0 0 0 0 0 0 0 0
Arg 0 0 0 0 0 0 1 0
His 0 1 1 0 0 0 0 0