Summary for peptidase C14.035: metacaspase Yca1 (Saccharomyces cerevisiae-type)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Namemetacaspase Yca1 (Saccharomyces cerevisiae-type)
Other namesAMca 2 (Allomyces metacaspase 2), CasA (Aspergillus fumigatus), CasB (Aspergillus fumigatus), CDP II (Allomyces arbuscula), Mca1 g.p. (Saccharomyces cerevisiae), metacaspase-1, Pca1 g.p. (Schizosaccharomyces pombe), yeast caspase-1, Yor197w g.p. (Saccharomyces cerevisiae)
Domain architecture
MEROPS Classification
Classification Clan CD >> Subclan (none) >> Family C14 >> Subfamily B >> C14.035
Holotypemetacaspase Yca1 (Saccharomyces cerevisiae-type), Uniprot accession Q08601 (peptidase unit: 135-329), MERNUM MER0039482
History Identifier created: MEROPS 6.9 (16 December 2004)
Activity
Catalytic typeCysteine
NC-IUBMBNot yet included in IUBMB recommendations.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/g/-/RScissile bond-/-/-/- (based on 11 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 4 1 0 0 0 0 0
Pro 0 0 2 0 0 0 0 0
Ala 0 1 0 0 0 0 0 0
Val 1 1 1 0 0 0 0 0
Leu 0 0 1 0 0 0 0 0
Ile 0 0 0 0 0 0 0 0
Met 0 0 0 0 0 0 0 0
Phe 0 1 0 0 0 0 0 0
Tyr 0 0 0 0 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 0 0 0 0 0 0 0 0
Thr 0 0 0 0 0 0 0 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 0 0 0
Gln 0 0 0 0 0 0 0 0
Asp 0 0 0 0 0 0 0 0
Glu 0 0 0 0 0 0 0 0
Lys 0 1 1 2 0 0 0 0
Arg 0 0 3 9 0 0 0 0
His 0 0 0 0 0 0 0 0