Summary for peptidase C15.001: pyroglutamyl-peptidase I (prokaryote)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors


MEROPS Namepyroglutamyl-peptidase I (prokaryote)
Other names5-oxoprolyl-peptidase, pyrase, pyroglutamyl aminopeptidase, pyrrolidone carboxyl peptidase, pyrrolidone-carboxylate peptidase
Domain architecture
MEROPS Classification
Classification Clan CF >> Subclan (none) >> Family C15 >> Subfamily (none) >> C15.001
Holotypepyroglutamyl-peptidase I (prokaryote) (Bacillus amyloliquefaciens), Uniprot accession P46107 (peptidase unit: 1-215), MERNUM MER0001424
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Catalytic typeCysteine
PeplistIncluded in the Peplist with identifier PL00105
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.19 (Omega peptidases) >> Peptidase
EnzymologyBRENDA database
BiotechnologyRemoval of pyroglutamyl groups from peptides, in protein sequencing. Laboratory use in identification of group A streptococci and enterococci.
PhysiologyRemoval of pyroglutamyl groups from peptides in protein catabolism.