Summary for peptidase C15.010: pyroglutamyl-peptidase I (chordate)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Human EST Mouse EST Substrates Inhibitors

 

Names
MEROPS Namepyroglutamyl-peptidase I (chordate)
Other names5-oxoprolyl-peptidase, pyroglutamyl aminopeptidase, pyrrolidone-carboxylate peptidase
Domain architecture
MEROPS Classification
Classification Clan CF >> Subclan (none) >> Family C15 >> Subfamily (none) >> C15.010
Holotypepyroglutamyl-peptidase I (chordate) (Homo sapiens), Uniprot accession Q9NXJ5 (peptidase unit: 4-209), MERNUM MER0011032
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeCysteine
PeplistIncluded in the Peplist with identifier PL00106
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.19 (Omega peptidases) >> Peptidase 3.4.19.3
EnzymologyBRENDA database
Activity statushuman: active (Dando, 2004)
mouse: active (by similarity)
PhysiologyInactivates TRH and LHRH by removal of pyroglutamyl groups.
Other databases TREEFAMhttp://www.treefam.org/family/TF313278
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
PGPEP1 19p13.11 ENSG00000130517 54858 PGPEP1 610694
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Pgpep1 8:C1 ENSMUSG00000003989 66522 MGI:1913772