Summary for peptidase C15.010: pyroglutamyl-peptidase I (chordate)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Human EST Mouse EST Substrates Inhibitors


MEROPS Namepyroglutamyl-peptidase I (chordate)
Other names5-oxoprolyl-peptidase, pyroglutamyl aminopeptidase, pyrrolidone-carboxylate peptidase
Domain architecture
MEROPS Classification
Classification Clan CF >> Subclan (none) >> Family C15 >> Subfamily (none) >> C15.010
Holotypepyroglutamyl-peptidase I (chordate) (Homo sapiens), Uniprot accession Q9NXJ5 (peptidase unit: 4-209), MERNUM MER0011032
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Catalytic typeCysteine
PeplistIncluded in the Peplist with identifier PL00106
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.19 (Omega peptidases) >> Peptidase
EnzymologyBRENDA database
Activity statushuman: active (Dando, 2004)
mouse: active (by similarity)
PhysiologyInactivates TRH and LHRH by removal of pyroglutamyl groups.
Other databases TREEFAM
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
PGPEP1 19p13.11 ENSG00000130517 54858 PGPEP1 610694
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Pgpep1 8:C1 ENSMUSG00000003989 66522 MGI:1913772