Summary for peptidase C19.001: ubiquitin-specific peptidase 5

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors

 

Names
MEROPS Nameubiquitin-specific peptidase 5
Other namesisopeptidase T, Ubp1 (Homo sapiens), ubiquitin-specific protease 5, USP5 g.p. (Homo sapiens)
Domain architecture
MEROPS Classification
Classification Clan CA >> Subclan (none) >> Family C19 >> Subfamily (none) >> C19.001
Holotypeubiquitin-specific peptidase 5 (Homo sapiens), Uniprot accession P45974 (peptidase unit: 288-858), MERNUM MER0002066
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeCysteine
PeplistIncluded in the Peplist with identifier PL00108
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.1.2 () >> Peptidase 3.1.2.15
EnzymologyBRENDA database
Activity statushuman: active (Wilkinson, 2004)
mouse: active (Hemelaar et al., 2004)
PhysiologyRecycling of ubiquitin in ubiquitin-dependent proteolysis.
Other databases TREEFAMhttp://www.treefam.org/family/TF300576
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternL/R/G/GScissile bondk/-/-/- (based on 10 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 10 10 0 0 0 0
Pro 0 0 0 0 0 0 0 0
Ala 0 0 0 0 0 0 0 0
Val 0 0 0 0 0 0 0 0
Leu 9 1 0 0 0 0 2 0
Ile 0 0 0 0 0 1 1 0
Met 0 0 0 0 1 0 0 0
Phe 0 0 0 0 0 0 0 1
Tyr 0 0 0 0 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 0 0 0 0 0 0 1 0
Thr 0 0 0 0 0 1 0 2
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 0 0 0
Gln 0 0 0 0 0 2 1 0
Asp 0 0 0 0 0 0 0 1
Glu 0 0 0 0 0 1 0 1
Lys 0 0 0 0 4 0 0 0
Arg 0 9 0 0 0 0 0 0
His 0 0 0 0 0 0 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
USP5 12p13 ENSG00000111667 8078 USP5 601447
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Usp5 6:F2 ENSMUSG00000038429 22225 MGI:1347343