Summary for peptidase C19.016: ubiquitin-specific peptidase 7

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors

 

Names
MEROPS Nameubiquitin-specific peptidase 7
Other namesHAUSP, herpesvirus-associated ubiquitin-specific protease, ubiquitin-specific protease 7, USP7 g.p. (Homo sapiens)
Domain architecture
MEROPS Classification
Classification Clan CA >> Subclan (none) >> Family C19 >> Subfamily (none) >> C19.016
Holotypeubiquitin-specific peptidase 7 (Homo sapiens), Uniprot accession Q93009 (peptidase unit: 176-532), MERNUM MER0002896
History Identifier created: MEROPS 3.1 (22 December 1998)
Activity
Catalytic typeCysteine
PeplistIncluded in the Peplist with identifier PL00432
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (1 cleavage)
Pathways KEGGEpstein-Barr virus infection
KEGGFoxO signaling pathway
KEGGHerpes simplex infection
KEGGViral carcinogenesis
Other databases TREEFAMhttp://www.treefam.org/family/TF105667
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternL/R/G/GScissile bondK/-/eg/- (based on 12 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 12 12 0 1 2 0
Pro 0 0 0 0 0 0 0 3
Ala 0 0 0 0 0 0 0 0
Val 0 0 0 0 0 1 0 0
Leu 12 0 0 0 0 0 0 0
Ile 0 0 0 0 2 2 0 0
Met 0 0 0 0 1 0 0 0
Phe 0 0 0 0 0 0 0 0
Tyr 0 0 0 0 0 0 0 1
Trp 0 0 0 0 0 0 0 0
Ser 0 0 0 0 0 0 0 1
Thr 0 0 0 0 0 0 0 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 0 0 1
Gln 0 0 0 0 0 0 0 0
Asp 0 0 0 0 0 0 0 0
Glu 0 0 0 0 0 0 4 1
Lys 0 0 0 0 9 1 0 0
Arg 0 12 0 0 0 1 1 0
His 0 0 0 0 0 1 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
USP7 16p13.3 ENSG00000171616 7874 USP7 602519
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Usp7 16:A1 ENSMUSG00000022710 252870 MGI:2182061