Summary for peptidase C25.001: gingipain RgpA

Summary Alignment Sequences Sequence features Distribution Literature Substrates Inhibitors

 

Names
MEROPS Namegingipain RgpA
Other names95 kDa gingipain, Arg-gingipain, argingipain, gingipain, gingipain-1, gingivain, HRgpA g.p. (Porphyromonas gingivalis), gingipain R, gingipain R1, prR1 g.p. (Porphyromonas gingivalis), prR2 g.p. (Porphyromonas gingivalis), prtH g.p. (Porphyromonas gingivalis)
Domain architecture
MEROPS Classification
Classification Clan CD >> Subclan (none) >> Family C25 >> Subfamily (none) >> C25.001
Holotypegingipain RgpA (Porphyromonas gingivalis), Uniprot accession P28784 (peptidase unit: 228-578), MERNUM MER0001351
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeCysteine
PeplistIncluded in the Peplist with identifier PL00111
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.37
EnzymologyBRENDA database
Proteolytic eventsCutDB database (17 cleavages)
PhysiologyGenerates host C5a, degrades complement component C3, and has other postulated roles in disease process.
Pharmaceutical relevancePossible drug target in periodontitis. Suppression of pathogenicity of Porphyromonas gingivalis by gingipain inhibitor compounds KYT-1 and KYT-36 was described by Kadowaki et al. (2004).
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/lp/-/RScissile bond-/-/-/- (based on 26 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 1 1 0 4 1 5 5
Pro 0 5 2 0 0 3 3 0
Ala 1 0 1 0 4 2 0 0
Val 1 0 1 0 2 3 0 3
Leu 0 5 2 0 1 3 1 1
Ile 1 2 1 0 1 2 1 2
Met 1 0 1 0 0 0 2 0
Phe 0 1 1 0 0 2 1 0
Tyr 0 0 0 0 1 0 0 1
Trp 1 0 0 0 0 0 0 0
Ser 5 4 1 0 3 2 2 1
Thr 0 1 4 0 1 1 1 1
Cys 0 0 0 0 2 0 1 0
Asn 3 0 1 0 0 0 1 1
Gln 1 0 0 0 2 2 1 3
Asp 1 0 0 0 1 1 1 1
Glu 1 1 3 0 0 1 0 1
Lys 4 1 3 1 1 0 1 1
Arg 0 1 0 24 1 1 2 1
His 0 0 1 0 0 0 0 0