Summary for peptidase C25.002: gingipain Kgp

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Namegingipain Kgp
Other namesKgp g.p. (Porphyromonas gingivalis), Lys-gingipain, porphypain, PrtK g.p. (Porphyromonas gingivalis), prtP g.p. (Porphyromonas gingivalis)
Domain architecture
MEROPS Classification
Classification Clan CD >> Subclan (none) >> Family C25 >> Subfamily (none) >> C25.002
Holotypegingipain Kgp (Porphyromonas gingivalis), Uniprot accession P72194 (peptidase unit: 239-571), MERNUM MER0002599
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeCysteine
PeplistIncluded in the Peplist with identifier PL00112
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.47
EnzymologyBRENDA database
Proteolytic eventsCutDB database (15 cleavages)
PhysiologyCleaves C5a receptor. Degrades the procoagulant portion of H-kininogen.
Pharmaceutical relevancePossible drug target in periodontitis.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/KScissile bond-/-/-/- (based on 47 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 4 3 2 0 8 6 1 3
Pro 6 1 1 0 4 2 3 5
Ala 3 5 5 0 1 3 6 0
Val 2 4 2 0 4 4 1 3
Leu 0 2 3 0 4 3 4 2
Ile 2 4 4 0 1 1 1 1
Met 0 1 1 0 1 1 0 0
Phe 0 0 4 0 0 3 4 1
Tyr 4 1 2 0 0 2 1 0
Trp 0 1 0 0 0 0 0 0
Ser 4 7 3 0 3 0 2 2
Thr 4 2 3 0 3 2 3 3
Cys 0 1 0 0 0 0 1 2
Asn 4 0 4 0 2 2 1 2
Gln 1 2 2 0 1 3 0 3
Asp 0 1 2 0 1 3 1 2
Glu 0 3 2 0 2 0 4 1
Lys 0 0 1 46 3 2 0 2
Arg 3 0 2 1 4 3 6 3
His 2 2 0 0 0 0 1 1