Summary for peptidase C25.003: gingipain RgpB

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Namegingipain RgpB
Other names50 kDa gingipain, Arg-gingipain B, gingipain R2, RgpB g.p. (Porphyromonas gingivalis)
Domain architecture
MEROPS Classification
Classification Clan CD >> Subclan (none) >> Family C25 >> Subfamily (none) >> C25.003
Holotypegingipain RgpB (Porphyromonas gingivalis), Uniprot accession P95493 (peptidase unit: 230-580), MERNUM MER0002270
History Identifier created: MEROPS 3.21 (12 May 1999)
Activity
Catalytic typeCysteine
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (6 cleavages)
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/RkScissile bond-/-/-/- (based on 16 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 1 0 0 3 0 3 2
Pro 0 1 0 0 0 1 1 0
Ala 0 1 1 0 1 1 1 1
Val 0 1 1 0 0 1 1 0
Leu 1 1 0 0 0 1 0 2
Ile 0 1 1 0 1 0 0 0
Met 1 0 0 0 0 0 0 0
Phe 1 0 0 0 1 1 1 0
Tyr 1 1 1 0 0 1 0 1
Trp 0 0 0 0 0 0 0 0
Ser 3 2 1 0 1 1 3 0
Thr 0 0 2 0 2 1 0 0
Cys 0 0 0 0 0 0 0 0
Asn 1 1 1 0 0 1 1 1
Gln 2 0 0 0 1 0 0 0
Asp 0 0 0 0 0 1 0 1
Glu 0 0 2 0 0 0 1 1
Lys 0 2 2 4 1 1 0 2
Arg 0 0 2 12 2 0 0 1
His 3 2 1 0 2 4 2 2