Summary for peptidase C30.003: human coronavirus 229E main peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

 

Names
MEROPS Namehuman coronavirus 229E main peptidase
Other names3C-like protease, 3CLpro, Mpro, porcine epidemic diarrhea virus main peptidase
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(C) >> Family C30 >> Subfamily (none) >> C30.003
Holotypehuman coronavirus 229E main peptidase, Uniprot accession Q05002 (peptidase unit: 2966-3267), MERNUM MER0002026
History Identifier created: MEROPS 3.02 (25 June 1998)
Activity
Catalytic typeCysteine
PeplistIncluded in the Peplist with identifier PL00433
NC-IUBMBNot yet included in IUBMB recommendations.
PhysiologyViral polyprotein processing in replication.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternvst/-/L/QScissile bondSa/-/-/- (based on 11 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 0 0 1 3 1 0
Pro 1 0 0 0 0 0 0 0
Ala 0 1 0 0 3 2 1 0
Val 4 1 1 0 0 1 0 0
Leu 0 0 9 0 0 1 2 1
Ile 0 1 1 0 0 0 0 1
Met 0 0 0 0 0 0 0 0
Phe 0 0 0 0 0 1 0 0
Tyr 0 0 0 0 0 0 0 0
Trp 0 0 0 0 0 0 0 1
Ser 3 0 0 0 6 0 1 2
Thr 3 2 0 0 0 0 0 2
Cys 0 0 0 0 0 0 0 0
Asn 0 2 0 0 1 1 0 2
Gln 0 1 0 11 0 0 0 1
Asp 0 1 0 0 0 0 1 0
Glu 0 0 0 0 0 1 3 0
Lys 0 1 0 0 0 1 2 0
Arg 0 1 0 0 0 0 0 1
His 0 0 0 0 0 0 0 0