Summary for peptidase C37.001: calicivirin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Namecalicivirin
Other namesCamberwell virus processing peptidase, Chiba virus processing peptidase, norovirus NS6 endopeptidase, norovirus virus processing peptidase, Norwalk virus processing peptidase, Southampton virus processing peptidase
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(C) >> Family C37 >> Subfamily (none) >> C37.001
Holotypecalicivirin (Southampton virus), Uniprot accession Q04544 (peptidase unit: 1100-1272), MERNUM MER0002195
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeCysteine
PeplistIncluded in the Peplist with identifier PL00116
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.66
EnzymologyBRENDA database
Proteolytic eventsCutDB database (4 cleavages)
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/eh/L/QeScissile bondG/Pq/e/ds (based on 11 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 0 0 9 1 0 1
Pro 0 0 1 0 0 7 1 1
Ala 2 0 0 0 1 0 1 0
Val 1 0 1 0 0 0 0 0
Leu 1 0 7 0 0 0 0 1
Ile 1 1 0 0 0 0 0 0
Met 1 0 0 0 0 0 0 0
Phe 2 0 1 0 0 0 0 0
Tyr 3 0 0 0 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 0 1 0 0 0 0 0 2
Thr 0 1 1 0 1 0 0 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 0 1 0
Gln 0 0 0 8 0 2 0 0
Asp 0 0 0 0 0 0 1 5
Glu 0 4 0 3 0 0 6 0
Lys 0 1 0 0 0 1 1 0
Arg 0 0 0 0 0 0 0 1
His 0 3 0 0 0 0 0 0