Summary for peptidase C39.001: bacteriocin-processing peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

 

Names
MEROPS Namebacteriocin-processing peptidase
Other namesABC-protease, hetC processing peptidase (Anabaena sp.), processing peptidase comA (Streptococcus pneumoniae), processing peptidase EntT (Enterococcus faecium), processing peptidase lcnC (Lactobacillus lactis), processing peptidase mesD (Leuconostoc mesenteroides), processing peptidase PedD (Pediococcus sp.), processing peptidase sapT ( Lactobacillus sake)
Domain architecture
MEROPS Classification
Classification Clan CA >> Subclan (none) >> Family C39 >> Subfamily (none) >> C39.001
Holotypebacteriocin-processing peptidase (Pediococcus acidilactici), Uniprot accession P36497 (peptidase unit: 1-150), MERNUM MER0002036
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeCysteine
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (12 cleavages)
PhysiologyCleavage of leader peptide of bacteriocins during export from the organism.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternIv/-/G/GScissile bondkag/-/y/gs (based on 13 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 13 11 2 1 2 6
Pro 0 0 0 0 0 0 0 0
Ala 1 0 0 2 2 0 0 0
Val 4 2 0 0 0 0 0 0
Leu 0 2 0 0 0 1 0 0
Ile 7 3 0 0 0 0 0 0
Met 0 0 0 0 0 1 1 0
Phe 0 0 0 0 0 0 0 1
Tyr 0 1 0 0 0 3 4 1
Trp 0 0 0 0 0 0 1 1
Ser 0 1 0 0 0 1 2 3
Thr 1 3 0 0 1 2 1 0
Cys 0 0 0 0 0 0 0 0
Asn 0 1 0 0 1 0 1 0
Gln 0 0 0 0 0 1 0 0
Asp 0 0 0 0 1 0 0 0
Glu 0 0 0 0 0 0 0 0
Lys 0 0 0 0 6 1 0 0
Arg 0 0 0 0 0 2 0 1
His 0 0 0 0 0 0 1 0