Summary for peptidase C48.001: Ulp1 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates


MEROPS NameUlp1 peptidase
Domain architecture
MEROPS Classification
Classification Clan CE >> Subclan (none) >> Family C48 >> Subfamily (none) >> C48.001
HolotypeUlp1 peptidase (Saccharomyces cerevisiae), Uniprot accession Q02724 (peptidase unit: 439-592), MERNUM MER0005202
History Identifier created: MEROPS 5.0 (17 April 2000)
Catalytic typeCysteine
PeplistIncluded in the Peplist with identifier PL00118
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase
EnzymologyBRENDA database
Proteolytic eventsCutDB database (1 cleavage)
PhysiologyIn eukaryotes, protein function can be modulated by ligation to ubiquitin or to ubiquitin-like proteins including the vertebrate SUMO-1 and the yeast Smt3 proteins. The Ulp1 endopeptidase is a Saccharomyces cerevisiae peptidase that hydrolyses links between proteins and Smt3 or SUMO-1, but not ubiquitin. The pattern of Smt3-coupled proteins in yeast changes markedly throughout the cell cycle, and specific conjugates accumulate in ulp1-deficient mutants. Ulp1 has several functions, including an essential role in the G2/M phase of the cell cycle (Li & Hochstrasse, 1999).