Summary for peptidase C48.002: SENP1 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors

 

Names
MEROPS NameSENP1 peptidase
Other namesAxam protein, Axin-associating molecule, sentrin-specific peptidase 1, SUMO-1 peptidase, SuPr-1
Domain architecture
MEROPS Classification
Classification Clan CE >> Subclan (none) >> Family C48 >> Subfamily (none) >> C48.002
HolotypeSENP1 peptidase (Homo sapiens), Uniprot accession Q9P0U3 (peptidase unit: 456-614), MERNUM MER0011012
History Identifier created: MEROPS 5.0 (17 April 2000)
Activity
Catalytic typeCysteine
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (1 cleavage)
Activity statushuman: active (Gong et al., 2000)
mouse: active (Gong et al., 2000)
Other databases TREEFAMhttp://www.treefam.org/family/TF316289
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternQ/T/G/GScissile bondK/-/E/p (based on 32 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 32 32 0 0 0 0
Pro 0 0 0 0 0 1 0 7
Ala 0 0 0 0 0 0 2 0
Val 0 0 0 0 2 2 0 2
Leu 0 0 0 0 0 3 0 0
Ile 0 0 0 0 0 3 1 1
Met 0 0 0 0 0 1 0 1
Phe 0 0 0 0 0 1 1 0
Tyr 0 3 0 0 0 1 0 2
Trp 0 0 0 0 0 0 0 0
Ser 0 0 0 0 1 2 1 1
Thr 0 29 0 0 0 2 1 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 0 1 1
Gln 32 0 0 0 0 4 1 4
Asp 0 0 0 0 0 0 1 2
Glu 0 0 0 0 0 3 15 2
Lys 0 0 0 0 23 3 0 1
Arg 0 0 0 0 0 0 0 0
His 0 0 0 0 1 0 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
SENP1 12q13.1 ENSG00000079387 29843 SENP1
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Senp1 15:F2 ENSMUSG00000033075 223870 MGI:2445054