Summary for peptidase C54.003: autophagin-1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors

 

Names
MEROPS Nameautophagin-1
Other namesautophagy-related 4B, HsApg4B protein (obs.), HsAtg4B protein, ATG4B g.p. (Homo sapiens), Mername-AA007 peptidase
Domain architecture
MEROPS Classification
Classification Clan CA >> Subclan (none) >> Family C54 >> Subfamily (none) >> C54.003
Holotypeautophagin-1 (Homo sapiens), Uniprot accession Q9Y4P1 (peptidase unit: 28-342), MERNUM MER0013561
History Identifier created: MEROPS 5.4 (23 March 2001)
Activity
Catalytic typeCysteine
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (1 cleavage)
Activity statushuman: active (Marino et al., 2003)
mouse: active (by similarity to human)
Pathways KEGGRegulation of autophagy
Other databases TREEFAMhttp://www.treefam.org/family/TF314847
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternsegn/Tvl/F/GScissile bond-/-/-/- (based on 15 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 3 0 0 15 0 0 0 0
Pro 0 0 0 0 0 0 0 0
Ala 0 0 0 0 0 0 0 0
Val 0 4 0 0 0 0 0 0
Leu 0 2 0 0 1 1 1 0
Ile 0 0 0 0 0 0 0 0
Met 0 0 0 0 1 0 0 0
Phe 0 0 13 0 1 0 0 0
Tyr 0 0 2 0 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 5 0 0 0 0 0 0 2
Thr 0 9 0 0 0 0 0 0
Cys 0 0 0 0 1 0 0 0
Asn 3 0 0 0 0 0 0 0
Gln 0 0 0 0 0 0 0 0
Asp 0 0 0 0 0 0 0 0
Glu 4 0 0 0 0 0 1 0
Lys 0 0 0 0 1 1 0 0
Arg 0 0 0 0 0 0 0 0
His 0 0 0 0 0 0 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
ATG4B 2q37.3 ENSG00000168397 23192 APG4B 611338
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Atg4b 1:D ENSMUSG00000026280 66615 MGI:1913865