Summary for peptidase M01.002: lysyl aminopeptidase (bacteria)

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

 

Names
MEROPS Namelysyl aminopeptidase (bacteria)
Other namesaminopeptidase N (Gram positive bacteria)
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(E) >> Family M1 >> Subfamily (none) >> M01.002
Holotypelysyl aminopeptidase (bacteria) (Lactococcus lactis), Uniprot accession A2RI32 (peptidase unit: 239-419), MERNUM MER0001005
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00124
NC-IUBMBNot yet included in IUBMB recommendations.
PhysiologyBacterial nutrition.
Pathways KEGGGlutathione metabolism
KEGGMetabolic pathways
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/-Scissile bond-/-/-/- (based on 22 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 0 1 0 1 2 1
Pro 0 0 0 1 1 3 2 0
Ala 0 0 0 1 1 0 0 0
Val 0 0 0 0 0 0 1 1
Leu 0 0 0 3 0 0 0 1
Ile 0 0 0 0 0 0 0 0
Met 0 0 0 2 0 0 0 0
Phe 0 0 0 2 2 0 0 2
Tyr 0 0 0 2 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 0 0 0 0 0 1 1 1
Thr 0 0 0 0 1 1 0 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 0 0 0
Gln 0 0 0 1 1 0 0 0
Asp 0 0 0 0 0 1 1 0
Glu 0 0 0 0 2 2 1 0
Lys 0 0 0 6 1 1 1 1
Arg 0 0 0 1 1 0 0 0
His 0 0 0 2 1 1 1 2