Summary for peptidase M01.014: aminopeptidase B

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Nameaminopeptidase B
Other namesarylamidase II, chloride-activated arginine aminopeptidase, cytosol aminopeptidase IV, cytosol arginyl aminopeptidase
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(E) >> Family M1 >> Subfamily (none) >> M01.014
Holotypeaminopeptidase B (Rattus norvegicus), Uniprot accession O09175 (peptidase unit: 249-451), MERNUM MER0002755
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00130
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.11 (Aminopeptidases) >> Peptidase 3.4.11.6
EnzymologyBRENDA database
Proteolytic eventsCutDB database (1 cleavage)
Activity statushuman: active (Foulon et al., 2004)
mouse: active (by similarity to rat) (Fukasawa et al., 1999)
Other databases TREEFAMhttp://www.treefam.org/family/TF300758
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/RScissile bond-/-/-/- (based on 15 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 0 0 1 2 3 2
Pro 0 0 0 0 0 1 1 0
Ala 0 0 0 0 1 2 0 0
Val 0 0 0 0 0 0 2 0
Leu 0 0 0 0 0 1 0 0
Ile 0 0 0 0 0 1 0 0
Met 0 0 0 0 0 0 1 0
Phe 0 0 0 0 0 0 0 3
Tyr 0 0 0 0 2 1 0 1
Trp 0 0 0 0 0 0 0 0
Ser 0 0 0 0 1 0 0 0
Thr 0 0 0 0 0 0 1 0
Cys 0 0 0 0 0 0 0 1
Asn 0 0 0 0 0 0 0 0
Gln 0 0 0 0 0 1 1 0
Asp 0 0 0 0 1 1 1 2
Glu 0 0 0 0 0 0 0 1
Lys 0 0 0 3 2 1 0 0
Arg 0 0 0 12 2 0 1 1
His 0 0 0 0 1 0 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
RNPEP 1q32.1-q32.2 ENSG00000176393 6051 RNPEP 602675
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Rnpep 1:E4 ENSMUSG00000041926 215615 MGI:2384902