Summary for peptidase M01.018: endoplasmic reticulum aminopeptidase 1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Nameendoplasmic reticulum aminopeptidase 1
Other namesadipocyte-derived aminopeptidase, A-LAP, aminopeptidase associated with antigen processing in the ER, aminopeptidase PILS, aminopeptidase regulator of TNFR1 shedding, ARTS-1, ERAP-1, ERAAP, KIAA0525 protein (Homo sapiens), PILSAP, puromycin insensitive leucyl-specific aminopeptidase (PILSAP), type 1 tumor necrosis factor receptor shedding aminopeptidase regulator
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(E) >> Family M1 >> Subfamily (none) >> M01.018
Holotypeendoplasmic reticulum aminopeptidase 1 (Homo sapiens), Uniprot accession Q9NZ08 (peptidase unit: 269-479), MERNUM MER0005331
History Identifier created: MEROPS 3.30 (20 July 1999)
Activity
Catalytic typeMetallo
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (3 cleavages)
Activity statushuman: active (Hattori et al., 2000)
mouse: putative
PhysiologyConsidered to serve a specific function in trimming of antigenic peptides, exhibiting a strong preference for hydrolysis of substrate peptides 9-16 residues long, but sparing peptides of 8-9 residues, the length required for binding to MHC class I molecules (Chang et al., 2005).
Other databases TREEFAMhttp://www.treefam.org/family/TF300395
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/TlScissile bondV/dw/kna/Nkt (based on 76 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 0 0 0 1 0 1
Pro 0 0 0 0 0 3 2 1
Ala 0 0 0 1 2 3 13 1
Val 0 0 0 1 45 2 2 0
Leu 0 0 0 14 0 1 0 1
Ile 0 0 0 1 1 3 3 1
Met 0 0 0 3 1 1 1 0
Phe 0 0 0 3 1 0 3 2
Tyr 0 0 0 1 10 1 2 0
Trp 0 0 0 0 0 9 0 0
Ser 0 0 0 0 3 0 0 1
Thr 0 0 0 45 0 3 0 7
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 8 14 34
Gln 0 0 0 0 0 1 1 0
Asp 0 0 0 1 0 29 1 1
Glu 0 0 0 0 0 1 0 0
Lys 0 0 0 2 2 1 25 16
Arg 0 0 0 3 2 0 0 0
His 0 0 0 1 1 1 1 1
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
ERAP1 5q15 ENSG00000164307 51752 606832
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Arts1 13:C1 ENSMUSG00000021583 80898 MGI:1933403