Summary for peptidase M01.024: ERAP2 aminopeptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Pharma

 

Names
MEROPS NameERAP2 aminopeptidase
Other namesaminopeptidase MAMS, L-RAP, endoplasmic reticulum aminopeptidase 2 (ERAP2), leukocyte-derived arginine aminopeptidase, Mername-AA066 peptidase
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(E) >> Family M1 >> Subfamily (none) >> M01.024
HolotypeERAP2 aminopeptidase (Homo sapiens), Uniprot accession Q6P179 (peptidase unit: 281-499), MERNUM MER0002968
History Identifier created: MEROPS 5.61 (29 October 2001)
Activity
Catalytic typeMetallo
NC-IUBMBNot yet included in IUBMB recommendations.
Other databases TREEFAMhttp://www.treefam.org/family/TF300395
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/-Scissile bond-/ptv/p/gp (based on 23 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 0 0 0 0 2 6
Pro 0 0 0 0 0 7 8 4
Ala 0 0 0 2 2 0 0 0
Val 0 0 0 1 3 3 1 1
Leu 0 0 0 1 0 0 0 0
Ile 0 0 0 2 2 2 1 0
Met 0 0 0 0 0 0 0 0
Phe 0 0 0 2 0 0 1 2
Tyr 0 0 0 3 3 1 2 2
Trp 0 0 0 0 0 0 0 0
Ser 0 0 0 0 0 0 0 0
Thr 0 0 0 4 4 3 1 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 2 0 0 0 0
Gln 0 0 0 0 1 1 1 1
Asp 0 0 0 1 1 1 1 1
Glu 0 0 0 0 0 0 0 0
Lys 0 0 0 3 0 0 0 0
Arg 0 0 0 2 2 0 0 0
His 0 0 0 0 1 1 1 1
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
ERAP2 5q15 ENSG00000164308 64167 609497